Endocrine Abstracts

Background: This study aimed to investigate neurocognitive functions and electroencephalography (EEG) parameters in normoglycemic obese children.Method: A total of 73 obese children (38 male and 35 female) and 42 healthy children (21 male and 21 female) were recruited. Biochemical disturbances and insulin resistance (IR) were investigated. The Wechsler Intelligence Scale for Children-Revised (WISC-R) and EEG were performed for all children. Obese partici...

Resin-based composite materials have become most used in restorative dentistry as a result of continuous effort to reduce the use of dental amalgam. Since 2018, it has been banned in children under 15 years of age, pregnant and nursing women. As these materials often contain bisphenol A glycidyl methacrylate (Bis-GMA) or derived monomers, bisphenol A (BPA), known for its endocrine disrupting effects, may be released and represent a low-dose and long-term source of BPA for the ...

Background: Patients with latent autoimmune diabetes in adults (LADA) are a clinically, immunologically, genetically heterogeneous group and the presence of thyroid autoimmunity (TA) appears to contribute to his heterogeneity.The aim was to evaluate the impact of TA on microangiopathic complications in LADA patients.Materials and method: LADA has been defined by the onset of diabetes at ages above 30 years, the lack of need for ins...

Background: Adrenocortical carcinoma (ACC) is a very rare and aggressive, endocrine malignancy with still limited treatment options. Approximately 60% of patients with ACC show endogenous glucocorticoid excess which could be one potential cause, why first clinical trials with immunotherapies, like immune checkpoint inhibitors, showed only modest results. Due to the lack of an ACC-specific antigen structure, other immunotherapeutic approaches, like specialized cancer treatments...

Background: Obesity is increasingly becoming prevalent among the general population and in patients with type 2 diabetes mellitus in particular. This unhealthy association contributes to increased morbidity and mortality from cardiovascular complications in diabetic patients.Objectives: The aim of this study is to determine the prevalence of obesity among type 2 diabetes mellitus patients.Materials...

Background: Obesity is increasingly becoming prevalent among the general population and in patients with type 2 diabetes mellitus in particular. This unhealthy association contributes to increased morbidity and mortality from cardiovascular complications in diabetic patients.Objectives: The aim of this study is to determine the prevalence of obesity among type 2 diabetes mellitus patients.Materials...

Background: Fatty acid desaturase 1 (FADS1) gene controls the fatty acid metabolism pathway in the human body (Sergeant et al., 2012). Single nucleotide polymorphism (SNP) in FADS1 gene and percentage of polyunsaturated fatty acids inserum lipids was associated (Klingel et al., 2018). Genetically predisposition to higher plasma arachidonic and stearic acid levels were associated with incidence oflarge-artery stroke and venous thromboembolism...

Insulinomas are predominantly benign pancreatic neuroendocrine tumors presenting with hyperinsulinemic hypoglycemia. Patients with significant hypoglycemic episodes can pose a management challenge. Based on the extent and the aggressiveness of the disease patients may be offered different treatment regimens. Although surgical resection is currently the standard treatment for pancreatic insulinoma, alternative treatment options, such as endoscopic ultrasound-guided fine needle ...

The determination of steroid hormones and subsequent interpretation of results is accompanied by a range of difficulties. The amount of information that current technology can provide on the circulating concentrations of more than a hundred various steroid compounds can lead to problems with interpretation. The aim of this study is to help provide orientation in this maze of data on steroid hormones. First, we focus on specific aspects arising from the pre-analytical phase of ...

Background: We investigated the frequency of autoimmune thyroid and diabetes antibodies in patients with type 1 diabetes mellitus (T1DM), their siblings, and controls.Methods: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), insulin autoantibodies (IAA), and thyroid antibodies were identified in all subjects.Results: The rates of positive GADA and IAA were significantly higher in probands compared to sibl...